研究業績

2023年

1. Tomio Morino, Noriyasu Kawai, Akira Ito, Takeshi Kobayashi, Takahiro Yasui. Novel nano-thermal ablation therapy using functionalized heat-generating nanoparticles for solid cancer treatment. World Journal of Cancer and Oncology Reserch. 2,592 (2023)
2. Yasuaki Tamura, Akira Ito, Kazumasa Wakamatsu, Toshihiko Torigoe, Hiroyuki Honda, Shosuke Ito, Kowichi Jimbow. A sulfur containing melanogenesis substrate, N-Pr-4-S-CAP as a potential source for selective chemoimmunotherapy of malignant melanoma. International Journal of Molecular Sciences. 24, 5235. https:// doi.org/10.3390/ijms24065235 (2023)
3. Masahiro Kaneko, Hiroto Yamazaki, Takahiro Ono, Masanobu Horie, Akira Ito. Effective magnetic hyperthermia induced by mitochondria-targeted nanoparticles modified with triphenylphosphonium-containing phospholipid polymers. Cancer Science. 114(9), 3750-3758 (2023)
4. Masahiro Kaneko, Airi Sato, Satoru Ayano, Akio Fujita, Goro Kobayashi, Akira Ito. Expansion of human mesenchymal stem cells on poly(vinyl alcohol) microcarriers. Journal of Bioscience and Bioengineering. 136(5), 407-414 (2023)
5. Masahiro Kaneko, Hiroaki Moriguchi, Ryo Futatsubashi, Satoru Ayano, Goro Kobayashi, Akira Ito.Transplantable cell-encapsulation device using a semipermeable ethylene-vinyl alcohol membrane in a mouse diabetic model. Journal of Bioscience and Bioengineering. 136(5), 415-422 (2023)

2022年

1. Yasuaki Tamura, Akira Ito, Kazumasa Wakamatsu, Takafumi Kamiya, Toshihiko Torigoe, Hiroyuki Honda, Toshiharu Yamashita, Hisashi Uhara, Shosuke Ito, Kowichi Jimbow. Immunomodulation of melanoma by chemo-thermo-immunotherapy using conjugates of melanogenesis Substrate NPrCAP and magnetite nanoparticles: a review. International Journal of Molecular Sciences. 23(12), 6457 (2022)
2. 金子真大，井藤　彰，ハイパーサーミアにおける酸化鉄ナノフラワーの開発 －ナノ構造と発熱能の関係－，Thermal Medicine. 38(3), 63-64 (2022)
3. Masahiro Kaneko, Akio Yamaguchi, Akira Ito. Induction of immunogenic cell death in murine colon cancer cells by ferrocene‐containing redox phospholipid polymers. Cancer Science. 113(10), 3558-3565 (2022)
4. Taisei Wakabayashi, Masahiro Kaneko, Tomoki Nakai, Masanobu Horie, Hiroyuki Fujimoto, Maazumi Takahashi, Shota Tanoue, Akira Ito, Nanowarming of vitrified pancreatic islets as a cryopreservation technology for transplantation. Bioengineering & Translational Medicine. https://doi.org/10.1002/btm2.10416
5. Kazumasa Wakamatsu, Akira Ito, Yasuaki Tamura, Tokimasa Hida, Takafumi Kamiya, Toshihiko Torigoe, Hiroyuki Honda, Shosuke Ito, Kowichi Jimbow. Molecular events in the melanogenesis cascade as novel melanoma-targeted small molecules: Principle and development. Cancers. 14(22), 10.3390/cancers14225588 (2022)
6. Ami Nishikawa, Yutaro Suzuki, Masahiro Kaneko, Akira Ito. Combination of magnetic hyperthermia and immunomodulators to drive complete tumor regression of poorly immunogenic melanoma. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-022-03345-8 (2022)

2021年

1. Kantaro Yoshioka, Akira Ito, Masanobu Horie, Kazushi Ikeda, Sho Kataoka, Keiichiro Sato, Taichi Yoshigai, Hidetoshi Sakurai, Akitsu Hotta, Yoshinori Kawabe, Masamichi Kamihira. Contractile activity of myotubes derived from human induced pluripotent stem cells: a model of Duchenne muscular dystrophy. Cells. 10(10), 2556 (2021)
2. Shinya Masumoto, Akihiko Ono, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira. Hypoxia-responsive expression of vascular endothelial growth factor for induction of angiogenesis in artificial three-dimensional tissues. Journal of Bioscience and Bioengineering. 132(4), 399-407 (2021)
3. Masahiro Kaneko, Masahito Ishikawa, Shuji Nakanishi, Kazuhiko Ishihara. Anticancer activity of cell-penetrating redox phospholipid polymers. ACS Macro Letters. 10(7), 926-932 (2021).
4. Kitano Hiroyuki, Nagae Yuki, Kawabe Yoshinori, Ito Akira, Kamihira Masamichi. Development of a genetically modified hepatoma cell line with heat-inducible high liver function. Cytotechnology. 73(3), 353-362 (2021)
5. Kantaro Yoshioka, Akira Ito, Md. Arifuzzaman, Taichi Yoshigai, Fangming Fan, Kei-ichiro Sato, Kazunori Shimizu, Yoshinori Kawabe, Masamichi Kamihira. Miniaturized skeletal muscle tissue fabrication for measuring contractile activity. Journal of Bioscience and Bioengineering. 131(4), 434-441 (2021)
6. Feiyang Zheng, Yoshinori Kawabe, Mai Murakami, Mamika Takahashi, Kyoka Nishihata, Souichiro Yoshida, Akira Ito, Masamichi Kamihira. LINE-1 vectors mediate recombinant antibody gene transfer by retrotransposition in Chinese hamster ovary cells. Biotechnology Journal. 16(7), 2000620 (2021)
7. Shinji Kawaguchi, Yusuke Soma, Kazuaki Nakajima, Hideaki Kanazawa, Shugo Tohyama, Ryota Tabei, Akinori Hirano, Noriko Handa, Yoshitake Yamada, Shigeo Okuda, Shuji Hishikawa, Takumi Teratani, Satoshi Kunita, Yoshikazu Kishino, Marina Okada, Sho Tanosaki, Shota Someya, Yuika Morita, Hidenori Tani, Yujiro Kawai, Masataka Yamazaki, Akira Ito, Rei Shibata, Toyoaki Murohara, Yasuhiko Tabata, Eiji Kobayashi, Hideyuki Shimizu, Keiichi Fukuda, Jun Fujita. Intramyocardial Transplantation ofHuman iPS Cell-Derived CardiacSpheroids Improves Cardiac Function inHeart Failure Animals. JACC: Basic to Translational Science. 6(3), 239-254 (2021).
8. 井藤　彰, 交流磁場照射による磁性ナノ粒子の発熱を引き金とした遺伝子発現システムの開発, Drug Delivery System, 36(3), 175-184 (2021)

2020年

1. Tomio Morino, Hiroshi Takase, Toshiki Etani, Taku Naiki, Noriyasu Kawai, Akira Ito, Takahiro Yasui, Medium temperature independent cytotoxicity of cell-adhesive heat-generating nanoparticles named magnetite cationic liposomes and its therapeutic use. Thermal Medicine. 36(1), 25-34 (2020).
2. Kantaro Yoshioka, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira, Novel neuromuscular junction model in 2D and 3D myotubes co-cultured with induced pluripotent stem cell-derived motor neurons. Journal of Bioscience and Bioengineering. 129(4), 486-493(2020).
3. Masahiro Kaneko, Kazuhiko Ishihara, Shuji Nakanishi. Redox-active polymers connecting living microbial cells to an extracellular electrical circuit. Small. 16(34), 2001849 (2020).
4. Tomio Morino, Shota Tanoue, Shuichiro Miyata, Kotaro Hirayama, Akira Ito, Toshiki Etani, Taku Naiki, Noriyasu Kawai, Takahiro Yasui, Heat dose index in vivo for cancer therapy using heat-generating nanoparticles named magnetite cationic liposomes and alternating magnetic field irradiator. Thermal Medicine. 36(2), 47-58 (2020).
5. Akira Ito, Kantaro Yoshioka, Shinya Masumoto, Keiichiro Sato, Yuki Hatae, Tomoki Nakai, Takashi Yamazaki, Masazumi Takahashi, Shota Tanoue, Masanobu Horie, Magnetic heating of nanoparticles as a scalable cryopreservation technology for human induced pluripotent stem cells. Scientific Reports. 10, 13605 (2020)
6. Tomio Morino, Akira Ito, Toshiki Etani, Taku Naiki, Noriyasu Kawai, Takahiro Yasui, Heat dose based large tumor treatment with multiple site injections of heat-generating nanoparticles dispersible within tumor tissue. Thermal Medicine. 36(4), 101-108 (2020).
7. 近藤隆、鈴木文男、水上達治、斎藤淳一、河合憲康、井藤　彰, ハイパーサーミアの新展開 -基礎医学・臨床応用に関する最近の進歩-, 放射線生物研究、55(3), 210-228(2020)

2019年

1. Md Arifuzzaman, Akira Ito, Kazushi Ikeda K, Yoshinori Kawabe, Masamichi Kamihira. Fabricating muscle-neuron constructs with improved contractile force generation.Tissue Engineering Part A. 2019 Apr;25(7-8):563-574. doi: 10.1089/ten.TEA.2018.0165. Epub 2018 Oct 27.
2. Akira Ito, Ryoji Teranishi, Kazuki Kamei, Masaki Yamaguchi, Akihiko Ono, Shinya Masumoto, Yuto Sonoda, Masanobu Horie, Yoshinori Kawabe, Masamichi Kamihira. Magnetically triggered transgene expression in mammalian cells by localized cellular heating of magnetic nanoparticles. Journal of Bioscience and Bioengineering. 2019 Apr 5. pii: S1389-1723(19)30052-0. doi: 10.1016/j.jbiosc.2019.03.008. [Epub ahead of print]
3. Paerwen Paerhati, Akira Ito, Kantaro Yoshioka, Kaori Iwamoto, Sho Fujiwara, Mamanobu Horie, Yoshinori Kawabe, Masamichi Kamihira. Neural differentiation of mouse induced pluripotent stem cells using cadherin gene-engineered PA6 feeder cells. Journal of Bioscience and Bioengineering. 2019 May;127(5):633-640. doi: 10.1016/j.jbiosc.2018.10.009. Epub 2018 Nov 1.
4. Ming Shi, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira, Targeted knock-in into the OVA locus of chicken cells using CRISPR/Cas9 system with homology-independent targeted integration. Journal of Bioscience and Bioengineering. 129(3), 363-370(2020).

2018年

1. Yoshinori Kawabe, Shinya Komatsu, Shodai Komatsu, Mai Murakami, Akira Ito, Tetsushi Sakuma, Takahiro Nakamura, Takashi Yamamoto, Masamichi Kamihira. Targeted knock-in of an scFv-Fc antibody gene into the hprt locus of Chinese hamster ovary cells using CRISPR/Cas9 and CRIS-PITCh systems. Journal of Bioscience and Bioengineering. 125(5), 599-605 (2018).
2. Xue Wang, Yoshinori Kawabe, Takeshi Hada, Akira Ito, Masamichi Kamihira. Cre-mediated transgene integration in Chinese hamster ovary cells using minicircle DNA vectors. Biotechnology Journal. e1800063. doi: 10.1002/biot.201800063 (2018).
3. 井藤　彰, ハイパーサーミアに伴う免疫賦活のメカニズム, 放射線生物研究, 53(2), 104-114 (2018)

2017年

1. Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Takeshi Omasa, Masamichi Kamihira, Improved recombinant antibody production by CHO cells using a production enhancer DNA element with repeated transgene integration at a predetermined chromosomal site. Journal of Bioscience and Bioengineering. 123(3), 390-397 (2017).
2. Kazushi Ikeda, Akira Ito, Ryusuke Imada, Masanori Sato, Yoshinori Kawabe, Masamichi Kamihira, In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. Scientific Reports. 7:44570 (2017). doi: 10.1038/srep44570.
3. Hirokazu Kaneko, Toshio Kokuryo, Yukihiro Yokoyama, Junpei Yamaguchi, Tokunori Yamamoto, Rei Shibata, Momokazu Gotoh, Toyoaki Murohara, Akira Ito, Masato Nagino, Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose. Surgery. 161(6), 1561?1569 (2017).
4. Akihiko Ono, Akira Ito, Tomonaga Sato, Masaki Yamaguchi, Taiga Suzuki, Yoshinori Kawabe, Masamichi Kamihira, Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain. Journal of Bioscience and Bioengineering. 124(1), 115-124. (2017)
5. Xue Wang , Yoshinori Kawabe, Ryuji Kato, Takeshi Hada, Akira Ito, Yoshimasa Yamana, Masako Kondo, Masamichi Kamihira, Accumulative scFv-Fc antibody gene integration into the hprt chromosomal locus of Chinese hamster ovary cells. Journal of Bioscience and Bioengineering. 124(5), 583-590 (2017).
6. Jane Marie Tonello, Saori Kawashima, Kazuki Sato, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira, Three-dimensional culture of a genetically modified hepatoma cell line using macroporous gelatin beads. Cytotechnology. 69(6):925-931.
7. Hideaki Yamamoto, Jane Marie Tonello, Takanori Sambuichi, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira, Characterization of genetically engineered mouse hepatoma cells with inducible liver functions by overexpression of liver-enriched transcription factors. Journal of Bioscience and Bioengineering. 125(1):131-139 (2017).
8. Kazushi Ikeda, Akira Ito, Masanori Sato, Shota Kanno, Yoshinori Kawabe and Masamichi Kamihira, Effects of heat stimulation and L-ascorbic acid 2-phosphate supplementation on myogenic differentiation of artificial skeletal muscle tissue constructs. Journal of Tissue Engineering and Regenerative Medicine. 11(5), 1322-1331 (2017).
9. Masanobu Horie, Anuj Tripathi, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira, Magnetite nanoparticles: Functionalization and manufacturing of pluripotent stem cells. Advanced Structured Materials, Springer, Germany, 66, pp.363-383 (2017)

2016年

1. Kazushi Ikeda, Akira Ito, Masanori Sato, Yoshinori Kawabe, Masamichi Kamihira, Improved contractile force generation of tissue-engineered skeletal muscle constructs by IGF-I and Bcl-2 gene transfer with electrical pulse stimulation. Regenerative Therapy. 3, 38-44 (2016). doi:10.1016/j.reth.2015.12.004.
2. Hiroki Takanari, Keiko Miwa, XianMing Fu, Jun-ichi Nakai, Akira Ito, Kousuke Ino, Hiroyuki Honda, Jun Kunishida, Satoru Konishi, Tobias Opthof, Marcel AG van der Heyden, Itsuo Kodama, Jong-Kook Lee, A new in vitro co-culture model using magnetic force-based nanotechnology. Journal of Cellular Physiology. 231(10), 2249-2256 (2016).
3. Yoshinori Kawabe, Takuya Shimomura, Shuohao Huang, Suguru Imanishi, Akira Ito, Masamichi Kamihira, Targeted transgene insertion into the CHO cell genome using Cre recombinase-incorporating integrase-defective retroviral vectors. Biotechnology and Bioengineering. 113(7), 1600-1610 (2016).
4. 李 鐘国, 井藤　彰, 本多裕之, 細胞操作, 磁気便覧, 丸善, p.14 （2016）
5. 井藤　彰, 磁気細胞操作技術による3次元細胞組織構築, ３次元細胞システム設計論, コロナ社, 東京, pp.38-50 (2016)

2015年

1. Akira Ito, Masahiro Yamamoto, Kazushi Ikeda, Masanori Sato, Yoshinori Kawabe, Masamichi Kamihira. Effects of type IV collagen on myogenic characteristics of IGF-I gene-engineered myoblast cells. Journal of Bioscience and Bioengineering. 119(5), 596-603 (2015).
2. Masanobu Horie, Akira Ito, Takeshi Maki, Yoshinori Kawabe, Masamichi Kamihira. Magnetic-labeled feeder system for mouse pluripotent stem cells. Journal of Bioscience and Bioengineering. 119(5), 614-616 (2015).
3. Takanori Inao, Yoshinori Kawabe, Takuro Yamashiro, Yujiro Kameyama, Xue Wang, Akira Ito, Masamichi Kamihira. Improved transgene integration into the CHO cell genome using the Cre-loxP system. Journal of Bioscience and Bioengineering. 120(1):99-106 (2015).
4. Akihiko Ono, Akira Ito, Taiga Suzuki, Masaki Yamaguchi, Yoshinori Kawabe, Masamichi Kamihira, DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification. Journal of Bioscience and Bioengineering. 120(4), 463-466 (2015).
5. 井藤　彰, 磁力を用いた細胞操作, 三次元ティッシュエンジニアリング-細胞の培養・操作・組織化から品質管理、脱細胞化まで, NTS, 東京, pp.121-128 (2015)

2014年

1. Yu Mizote, Kazumasa Wakamatsu, Shosuke Ito, Akiko Uenaka, Yoshihiro Ohue, Koji Kurose, Midori Isobe, Akira Ito, Yasuaki Tamura, Hiroyuki Honda, Toshiharu Yamashita, Satoshi Nohara, Mikio Oka, Kowichi Jimbow, Eiichi Nakayama, TLR4 and NLRP3 inflammasome activation 1 in monocytes by N-propionyl cysteaminylphenol-maleimid-dextran (NPCMD). Journal of Dermatological Science, 73(3), 209-215 (2014).
2. Akira Ito, Yasunori Yamamoto, Masanori Sato, Kazushi Ikeda, Masahiro Yamamoto, Hideaki Fujita, Eiji Nagamori, Yoshinori Kawabe, Masamichi Kamihira, Induction of functional tissue-engineered skeletal muscle constructs by defined electrical stimulation. Scientific Reports, 4, 4781; DOI:10.1038/srep04781(2014).
3. Masaki Yamaguchi, Akira Ito, Akihiko Ono, Yoshinori Kawabe, Masamichi Kamihira, Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles. ACS Synthetic Biology, 3(5), 273-279 (2014).
4. Masanori Sato, Kazushi Ikeda, Shota Kanno, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira, Enhancement of contractile force generation of artificial skeletal muscle tissues by mild and transient heat treatment. Current Pharmaceutical Biotechnology. 14(13), 1083-1087 (2014).
5. Masakazu Ishii, Rei Shibata, Yuuki Shimizu, Takashi Yamamoto, Kazuhisa Kondo, Yoko Inoue, Noriyuki Ouchi, Tohru Tanigawa, Noriyoshi Kanemura, Akira Ito, Honda Honda, Toyoaki Murohara. Multilayered adipose-derived regenerative cell sheets created by a novel magnetite tissue engineering method for myocardial infarction. International Journal of Cardiology. 175(3), 545-553 (2014).
6. 井藤　彰, 磁力を用いた細胞3次元組織化, 細胞の3次元組織化―その最先端技術と材料技術, メディカルドゥ, 大阪, pp. 300-304 (2014)